About Us
Research
Research
Latest Research News!
Background to research
Current Research
Previous Research Stories
Donating tissue for research
Donating tissue after death
Get Involved
Support
Giving & Events
Donate
Text Size
Contact Us
About Us
Our Background
Charity Origins
YBTC Impact Report 2019
YBTC Impact Report 2020
YBTC Impact Report 2021
The Good Business Charter
Our Team
Join Team YBTC
Meet Our Team
Meet Our Trustees
Meet Our Patrons & Celebrity Ambassadors
Meet Our Ambassadors
Meet Our Volunteers
Beefy's Charity Foundation
Current Funds
Safeguarding
Research
Research
Latest Research News!
Background to research
Current Research
Previous Research Stories
Donating tissue for research
Donating tissue after death
Get Involved
We want to hear from you!
YBTC Research Advisory Committee
Clinical Trials
Support
Support Services
Peer Support Groups
YBTC Support Line
Other Resources
Signs & Symptoms of a brain tumour
Mental Health & Wellbeing
Coping with the rising cost of living
Managing anxiety before a scan
Returning to work following a diagnosis
Travelling abroad after a diagnosis
Driving & transport after your diagnosis
Living with fatigue
Radiotherapy Masks
The Brain Tumour Patients' Charter of Rights
Giving & Events
Research
Research
Current Research
Developing tissue-on-chip technology
Developing tissue-on-chip technology
Developing tissue-on-chip technology to measure the response of brain tumours to established therapy and novel drugs.
Official Title:
Developing tissue-on-chip technology
Lead Researcher:
Dr Pedro Beltran-Alvarez
Where:
Hull and Leeds
When:
2020 - 2023
Cost:
£79,979
Research Type:
Adult & Paediatric, drug response
This is a collaborative project between the University of Hull and St James's, Leeds;
the Hull-Leeds brain tumour research bridge across Yorkshire.
The goal of this project is to further develop and establish a protocol that uses a miniature microfluidics chip to test every patients brain tumour with a selection of drugs. This means that the drugs found to be effective on chip could then be used to deliver an effective, personalised and precision medicine.
Yorkshire's Brain Tumour Charity are the sole funders of this three year project, starting in 2020.
A small manufactured plastic device, called a chip, keeps small pieces of brain tumour “alive” for eight days following surgery. The pieces of tumour used, taken from the operating theatre at Hull Teaching Hospital, are not required for clinical protocols. The patient does not undergo any additional risk or harm.
What is it?
The chip provides the brain tumour tissue with nutrients, removes waste products and keeps the tumour at body temperature so that cells remain viable. The aim is to develop treatments to predict tumour response to drugs. If this is achieved then the project will continue through larger clinical trials and developing a new model for personalized and precision medicine for brain tumour patients.
This model does not currently exist in brain tumour research and can enable the identification of patients who would benefit from new drugs.
Dr Pedro Beltran-Alvarez -
CLICK HERE
for more information
Dr Lucy Stead-
CLICK HERE
for more information
Dr Mark Wade -
CLICK HERE
for more information
Meet Antonia!
"My name is Antonia Barry and I’m from Newcastle, in the UK.
I graduated from the University of Leicester, in the summer of 2018, with a BSc with Honours in Medical Biochemistry, where I developed my passion for genetics and cancer research. I then spent a year researching proteasome inhibitor treatments in advanced prostate cancer, whilst working towards my MPhil at Newcastle University.
I have now begun the most exciting project in my career, that is, my PhD at the University of Hull.
I am studying novel drugs to treat brain tumours, under the supervision of Dr Pedro Beltran-Alvarez and Dr. Mark Wade (University of Hull) and Dr. Lucy Stead (University of Leeds). My project is funded by Yorkshire's Brain Tumour Charity and will hopefully make a difference to brain tumours very soon."
Publications
Antonia published her first research literature review paper on 6th January 2021. The paper collates recent advances in the understanding of the role of PRMTs (protein arginines methytransferases) and ArgMe (arginine methylation) in brain tumours. The paper looks at the relevance of PRMTs in brain tumours and possible routes for further research.
To view the full paper online
CLICK HERE.
Antonia also worked with Pedro Beltran-Alvarez on a paper, published on 9th August 2021, exploring the effect of PRMT-inhibiting drugs on platelet function.
To view the full paper online
CLICK HERE.
Since 2003 you've helped us raise:
4,807,665.73
Helpful Links
Registered Charity No. 1095931
Contact Us
Office: 0113 340 0111
Email:
info@yorksbtc.org.uk
Find Us
Yorkshire's Brain Tumour Charity
31 Otley Road,
Headingley,
Leeds,
LS6 3AA
Yorkshire's Brain Tumour Charity, Registered Charity Address 31 Otley Road, Headingley, Leeds, LS6 3AA.
© Yorkshire's Brain Tumour Charity. Registered Charity No. 1095931
Privacy Policy
|
Cookie Policy
|
Refund Policy
|
Fundraising Promise
|
Complaints Policy
|
Covid-19
by pixelbuilders.com |
digital agency leeds
Make a Donation