Developing tissue-on-chip technology

Developing tissue-on-chip technology to measure the response of brain tumours to established therapy and novel drugs.

Official Title: Developing tissue-on-chip technology
Lead Researcher: Dr Pedro Beltran-Alvarez
Where: Hull and Leeds
When: 2020 - 2023
Cost: £79,979
Research Type: Adult & Paediatric, drug response

This is a collaborative project between the University of Hull and St James's, Leeds; the Hull-Leeds brain tumour research bridge across Yorkshire.

The goal of this project is to further develop and establish a protocol that uses a miniature microfluidics chip to test every patients brain tumour with a selection of drugs. This means that the drugs found to be effective on chip could then be used to deliver an effective, personalised and precision medicine.

Yorkshire's Brain Tumour Charity are the sole funders of this three year project, starting in 2020.

A small manufactured plastic device, called a chip, keeps small pieces of brain tumour “alive” for eight days following surgery. The pieces of tumour used, taken from the operating theatre at Hull Teaching Hospital, are not required for clinical protocols. The patient does not undergo any additional risk or harm.

What is it?

The chip provides the brain tumour tissue with nutrients, removes waste products and keeps the tumour at body temperature so that cells remain viable. The aim is to develop treatments to predict tumour response to drugs. If this is achieved then the project will continue through larger clinical trials and developing a new model for personalized and precision medicine for brain tumour patients.

This model does not currently exist in brain tumour research and can enable the identification of patients who would benefit from new drugs.

Dr Pedro Beltran-Alvarez - CLICK HERE for more information
Dr Lucy Stead- CLICK HERE for more information

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