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Research News


Thu 25 February

Research might pave the way for future drug trials that aim to improve the effectiveness of our current treatments for high-grade brain tumours, and give patients and their families some much needed improvements in survival rates.
The work from Natasha Carmell's YBTC supported PhD has just been published this week:

Glioblastomas are high-grade brain tumours and are the most common form of malignancy arising in the brain. Patient survival has improved little over the last 40 years, highlighting an urgent unmet need for more effective treatments for these tumours.

The current standard-of-care treatment involves surgical removal of as much of the tumour as possible, followed by a course of chemotherapy or radiotherapy. The main chemotherapeutic drug used is called temozolomide, taken as a tablet.

However even with this treatment regimen, the average patient survival following diagnosis is around 15 months. This research has identified a protein called ERK5 which is present at higher levels in these high-grade brain tumours compared to normal brain tissue, and which is also associated with resistance to temozolomide and poor patient survival.

Additionally, they have shown that targeting ERK5 in brain tumour cells can improve the effectiveness of temozolomide in killing these tumour cells and offers potential much-needed future clinical benefit to patients diagnosed with glioblastoma.

To see a full copy of the research "Identification and Validation of ERK5 as a DNA Damage Modulating Drug Target in Glioblastoma", please CLICK HERE.

To see more about Natasha's funded PhD, please CLICK HERE.


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