Multi-coloured cells - new research paper

Thu 22 October

New research shows some genes in brain cancer cells are more active at different points of the cell cycle.

New research has been published today titled, "The cell cycle state defines TACC3 as a regulator gene in glioblastoma" with authors Briggs, H., Polson E.S., Irving B.K., Zougman A., Mathew R.K., Gendoo D.M.A. and Wurdak H.

The research has been funded by the Medical Research Council UK ( New Invesitgator Awards MR/J001171/1), Candlelighters and us here at Yorkshire's Brain Tumour Charity.

Ryan Mathew, whose Associate Professorship is part funded by YBTC, told us, "This is our new research paper. It shows how some genes in brain cancer cells are more active at different points of the cell cycle. If glioma wasn’t complicated enough, add that to the mix!"

What does the research mean?

Cancer cells rapidly make copies of themselves, which is how tumours grow.

There are 4 stages that each cell goes through during the copying process – this is called the ‘cell cycle.’ Genetic information (genes) inside the cells controls how the cell progresses through the cell cycle.

By making glioblastoma cells light up different colours when they are in the 4 different stages of the cell cycle we could look at how the genetic control changes over the duration of the entire cycle.

Previously, it was thought that genes controlled each stage an equal amount in brain cancer. But we found that some genes, that are dependent on a ‘master’ gene – called TACC3 - are more active at particular stages.

Understanding this is important when developing new treatments as researchers need to take into account that there is a ‘moving target’ depending on what stage the cell cycle is at.

To see a scientific summary online CLICK HERE or to download a copy of the paper please CLICK HERE

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